Cancer BiologyCancer Research CommunicationsPeer-reviewed
Febuxostat enhances the anti-tumor efficacy of 2-fluoroadenine and 5-methylthioadenosine in MTAP-deleted cancer
Baiqing Tang, Hyung‐Ok Lee, Daniel Krzizike…·Warren D. Kruger
The paper shows that adding febuxostat to 2FA and MTA increases their anti-tumor effect in MTAP-deleted cancer by reducing XO activity and increasing 2FAMP levels.
DOI 10.1158/2767-9764.crc-26-0193