TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination
Julia Halford, Amanda J. Senatore, Sage Berryman, Antonio Muñoz, Destinee Semidey, Ryan A. Doan, Adam M. Coombs, Brandon Noimany, Katie Emberley, Ben Emery, Kelly R. Monk, Swetha E. Murthy
This study identifies TMEM63A as a critical regulator of myelination in the CNS, showing its role in oligodendrocyte function and linking its dysfunction to hypomyelinating leukodystrophies.
Proceedings of the National Academy of Sciences · Jul 21, 2025Peer-reviewedNeuroscience