Author

Margherita Botticelli

University of BirminghamORCID 0009-0004-7025-7087Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Systems Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Approach:simulation· 1

Frequent Co-Authors

Fabian SpilliD· 2 shared John MetzcariD· 2 shared Pradeep KeshavanarayanaiD· 2 shared Paul MackliniD· 1 shared Susan CoxiD· 1 shared Thomas A. PhillipsiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersSystems Biology

Fabian SpillORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Systems BiologybioRxivPreprintSep 2, 2025

The role of contact guidance and ECM remodelling in cancer invasion: a computational study

Margherita Botticelli, John Metzcar, Paul Macklin…·Fabian Spill

This paper develops a computational model to study how cancer cells interact with and remodel the extracellular matrix, revealing how structural and chemical cues influence invasion.

DOI 10.1101/2025.09.02.673661

statistical modelsimulation

𝕏 PostBluesky

Systems BiologyFrontiers in Bioengineering and BiotechnologyPeer-reviewedApr 9, 2025

A hybrid computational model of cancer spheroid growth with ribose-induced collagen stiffening

Margherita Botticelli, John Metzcar, Thomas A. Phillips…·Fabian Spill

This study uses a hybrid computational model to show that increased ECM stiffness inhibits invasion in aggressive cancer cells but not in non-invasive ones.

5 citations

statistical modelexperimental assay

𝕏 PostBluesky