John Metzcar

This study develops a multicellular agent-based model to simulate nanoparticle interactions in cancer therapy and evaluates how pharmacokinetic parameters and therapeutic strategies affect tumor dynamics.

This paper develops a computational model to study how cancer cells interact with and remodel the extracellular matrix, revealing how structural and chemical cues influence invasion.

The paper introduces a framework for mathematical modeling of multicellular systems using interpretable cell behavior rules derived from biological knowledge and multi-omics data.

This study uses a hybrid computational model to show that increased ECM stiffness inhibits invasion in aggressive cancer cells but not in non-invasive ones.

The paper introduces a simplified agent-based framework for modeling cell-ECM interactions using PhysiCell, demonstrating its utility in various biological processes.