Author

Alexander R. Boucher

University of Massachusetts Chan Medical SchoolORCID 0009-0004-8212-453XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Abigail O. SmithiD· 1 shared David A. GuertiniD· 1 shared Derek B. AllisoniD· 1 shared Ekaterina D. KorobkinaiD· 1 shared Flaviane de Fátima SilvaiD· 1 shared Gregory J. PazouriD· 1 shared Huawei LiiD· 1 shared Kuang SheniD· 1 shared

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Abigail O. SmithORCID

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1 paper

Recent·Most cited

Cell BiologybioRxivPreprintJul 24, 2025

Rag GTPases Suppress Renal Cystic Disease by Inhibiting TFEB Independently of mTORC1

Flaviane de Fátima Silva, Alexander R. Boucher, Huawei Li…·David A. Guertin

This study shows that Rag GTPases suppress renal cystic disease by inhibiting TFEB, independent of mTORC1, and identifies nuclear TFEB as a better biomarker than mTORC1 activation.

1 citation

mousegenetic perturbation / CRISPR

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