Author

Flaviane de Fátima Silva

University of Massachusetts Chan Medical SchoolORCID 0000-0003-1937-1939Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

David A. GuertiniD· 2 shared Ekaterina D. KorobkinaiD· 2 shared Huawei LiiD· 2 shared Maria Gaughan· 2 shared Qingbo CheniD· 2 shared Abigail O. SmithiD· 1 shared Alan C. MulleniD· 1 shared Alexander R. BoucheriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPhysiology

David A. GuertinORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintAug 5, 2025

UCP1 Mitigates Hepatic Steatosis and Fibrosis Independent of Cold Exposure

John D. Haley, Johnny Le, Rui Li…·David A. Guertin

This study shows diet-induced thermogenesis reduces adiposity and protects against liver disease in male mice, with UCP1 playing a key role in BAT and non-adipocyte cells.

DOI 10.1101/2025.08.05.666925

mousebulk RNA-seq

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Cell BiologybioRxivPreprintJul 24, 2025

Rag GTPases Suppress Renal Cystic Disease by Inhibiting TFEB Independently of mTORC1

Flaviane de Fátima Silva, Alexander R. Boucher, Huawei Li…·David A. Guertin

This study shows that Rag GTPases suppress renal cystic disease by inhibiting TFEB, independent of mTORC1, and identifies nuclear TFEB as a better biomarker than mTORC1 activation.

1 citation

mousegenetic perturbation / CRISPR

𝕏 PostBluesky