Derek B. Allison

This study shows systemic hypoxia promotes lung adenocarcinoma progression by mobilizing glycogen via GAA, supporting tumor growth through metabolic remodeling.

The paper identifies PLK1-mediated phosphorylation of PHGDH as a mechanism driving serine metabolism reprogramming in advanced prostate cancer, increasing reliance on exogenous serine uptake.

This study identifies mTORC1's role in regulating the CCL24-CCR3 axis, showing its impact on granuloma formation and maintenance in sarcoidosis, with therapeutic implications.

This study shows that Rag GTPases suppress renal cystic disease by inhibiting TFEB, independent of mTORC1, and identifies nuclear TFEB as a better biomarker than mTORC1 activation.

This study shows that PLK1-mediated PDHA1 phosphorylation impairs mitochondrial function and promotes Cr(VI)-induced lung cancer progression by disrupting energy metabolism and apoptosis.

This study identifies hyper-glycosylation as a driver of Alzheimer's disease through metabolic analysis and interventions, showing its impact on cognitive decline and mortality.

This study shows that cervical spinal cord injury in rats leads to acute lung injury and metabolic dysfunction, establishing a new animal model for studying this relationship.

The paper introduces Madi, a workflow combining MALDI-MSI and machine learning to analyze FFPE tissues, revealing metabolic patterns and pathological features in human tissues.