SQ109 is a Novel Multitarget Antifungal in Pathogenic Yeasts: Membrane-Active Δ8,14 Sterol Remodeling, Bioenergetic Stress, and Vacuolar Dysfunction
Ruijie Zhou, Akanksha M. Pandey, Davinder Singh, Adi Jaiswal, Nicholas J. Rohlwing, Annie Le, Jamie Koo, Zi Ying Ong, Jayannah Herdrich, Yiyuan Chen, Fangrong Li, Mingdi He, Ben Mazurek, Ji-Hee Ko, Monishaa Murali, Eric Oldfield
This paper shows SQ109 targets multiple pathways in pathogenic yeasts, causing sterol accumulation, proton gradient collapse, and vacuolar dysfunction, leading to antifungal synergy and low resistance.
bioRxiv · Aug 11, 2026 · PreprintMicrobiology