Ruijie Zhou

This paper shows SQ109 targets multiple pathways in pathogenic yeasts, causing sterol accumulation, proton gradient collapse, and vacuolar dysfunction, leading to antifungal synergy and low resistance.

This study evaluates SQ109's antifungal activity against sixteen fungal pathogens and identifies its mechanisms involving mitochondrial targeting and isoprenoid biosynthesis pathway inhibition.

The paper tests carbazole, aminoguanidine, and diamine anti-infectives against Toxoplasma gondii, finding low IC50 values and protonophore uncoupling activity.