Author

Aditya Jignesh Khandeshi

National Institutes of HealthORCID 0009-0004-8541-1702Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aisha AhmediD· 1 shared Alessandro Ori‬‬iD· 1 shared Anantharaman ShantaramaniD· 1 shared Andrea MalaspinaiD· 1 shared Anna‐Leigh BrowniD· 1 shared Björn OskarssoniD· 1 shared Casey N. CookiD· 1 shared Cédric BelairiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Aisha AhmedORCID

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1 paper

Recent·Most cited

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

Sahba Seddighi, Yue Andy Qi, Anna‐Leigh Brown, Oscar G. Wilkins, Colleen Bereda, Cédric Belair, Yong‐Jie Zhang, Mercedes Prudencio, Matthew J. Keuss, Aditya Jignesh Khandeshi, Sarah R. Pickles, Sarah E. Kargbo-Hill, James Hawrot, Daniel M. Ramos, Hebao Yuan, , Michael Emmerson Ward

The paper shows that loss of TDP-43 function leads to the expression of de novo proteins from mis-spliced mRNA transcripts in ALS/FTD.

Science Translational Medicine · Jan 26, 2024Peer-reviewedNeuroscience