Alessandro Ori‬‬

A scalable human neuron model of Alzheimer's disease relevant tauopathy reveals mechanisms linking Tau fibrillization to synaptic dysfunction

This paper develops scalable human neuron models of Alzheimer's disease to reveal mechanisms linking Tau fibrillization to synaptic dysfunction and identifies therapeutic targets.

The PSD-95 interactome of hippocampal synapses potentiated in response to an in vivo learning task

The paper characterizes the PSD-95 interactome of hippocampal synapses potentiated by an in vivo learning task using a genetically encoded probe and mass spectrometry.

Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation

The paper identifies LMOD1 as a key regulator of myogenic differentiation through proteome dynamics and functional studies.

Direct RNA Sequencing reveals epitranscriptomic regulation of brain cells and Alzheimer's Disease pathology

This study uses direct RNA sequencing to analyze epitranscriptomic changes in brain cells, revealing m6A modification patterns linked to Alzheimer's disease progression.

Gene function and expression profiling in yeast spores, killifish diapause embryos, and their post-dormant offspring cells

The paper compares gene function and expression in dormant cells of yeast spores and killifish diapause embryos, finding conserved transcriptomic and proteomic changes across species.

Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains

This study shows oxidative stress reduces DUB activity in aging brains, which can be reversed with antioxidants, suggesting a reversible cause of proteostasis decline.

Convergent molecular signatures of ageing and injury in the peripheral nervous system

This study compares molecular changes in PNS ageing, dietary restriction, and injury, finding similar proteomic signatures between ageing and injury.

The microcephaly-associated protein YIPF5 differentially regulates ER-export

This study shows YIPF5 regulates ER export of specific proteins, and its disruption causes neuronal migration defects and microcephaly.

Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder

The paper creates a cell-type-specific lysosome protein atlas in the brain, identifies SLC45A1 as a neuron-specific lysosomal protein, and shows its role in lysosomal function and neurodegeneration.

Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis

This study identifies polyamines as key regulators of epithelial regeneration in aged intestines, showing they enhance protein homeostasis and restore regenerative capacity through dietary manipulation.

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4

The paper introduces the Neurolipid Atlas, a lipidomics resource for neurodegenerative diseases, revealing that ApoE4 impairs astrocyte reactivity by promoting cholesterol ester accumulation.

Lonafarnib Partially Reverses Cardiac Senescence in Human and Mouse Progeria Models via Autophagy Activation

This study identifies lonafarnib as a potential therapy for progeria-related cardiac senescence by activating autophagy and reducing progerin expression in human and mouse models.

Fetal-like reversion in the regenerating intestine is regulated by mesenchymal Asporin

The paper shows that mesenchymal Asporin mediates fetal-like reprogramming in regenerating intestinal epithelium by modulating Tgfβ signaling through CD44.

iSODA: A Comprehensive Tool for Integrative Omics Data Analysis in Single- and Multi-Omics Experiments

iSODA is a web-based tool for analyzing single- and multi-omics data, offering visualization, normalization, and integration methods like MOFA and SNF.

The Aging Synapse: An Integrated Proteomic And Transcriptomic Analysis

This study investigates changes in the synaptic proteome and transcriptome during aging, revealing decoupling between transcripts and proteins and altered ribosomal gene distribution.

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

The paper shows that loss of TDP-43 function leads to the expression of de novo proteins from mis-spliced mRNA transcripts in ALS/FTD.

Remodeling of the protein ubiquitylation landscape in the aging vertebrate brain

This study identifies age-related changes in ubiquitylation, acetylation, and phosphorylation sites in mouse brains and finds conserved effects in killifish, linking proteasome inhibition to aging ubiquitylome remodeling.

Transcriptome analysis of different strains of the turquoise killifish Nothobranchius furzeri identifies signatures associated with heritable lifespan differences

Human NMDAR autoantibodies disrupt excitatory-inhibitory balance leading to hippocampal network hypersynchrony

This study shows that NMDAR autoantibodies disrupt the excitatory-inhibitory balance in the hippocampus, leading to network hypersynchrony and symptoms resembling schizophrenia.

Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain

The paper shows that aging in killifish brains reduces basic amino acid-rich proteins through translation pausing, not transcription or proteasome issues, revealing a vulnerability in nucleic-acid protein biogenesis.

Novel biochemical, structural and systems insights into inflammatory signaling revealed by contextual interaction proteomics

The paper presents an integrated experimental and computational strategy to model protein-protein interactions in cellular context, applied to the TNF-receptor signaling complex.

Conserved exchange of paralog proteins during neuronal differentiation

The paper identifies conserved paralog substitutions during neuronal differentiation across species and shows their impact on neuron development.

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

This study shows that reduced proteasome activity in aging brains leads to ribosome stoichiometry loss and aggregation, increasing mortality risk in killifish.

Rapid proteotyping reveals cancer biology and drug response determinants in the NCI-60 cells

This study rapidly generates proteomic data for NCI-60 cancer cell lines and identifies drug response determinants by integrating proteomic, genetic, and transcriptomic data.

Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging.

The paper compares liver proteomes of long-lived naked mole-rats and short-lived guinea pigs to identify molecular networks linked to longevity and human aging.