Author

Yong‐Jie Zhang

Mayo ClinicORCID 0000-0002-9900-4313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Leonard PetrucelliiD· 2 shared Aaron HeldiD· 1 shared Aditya Jignesh KhandeshiiD· 1 shared Aisha AhmediD· 1 shared Alessandro Ori‬‬iD· 1 shared Alice S. Chen‐PlotkiniD· 1 shared Anantharaman ShantaramaniD· 1 shared Andrea MalaspinaiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Leonard PetrucelliORCID

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2 papers

Recent·Most cited

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

Sahba Seddighi, Yue Andy Qi, Anna‐Leigh Brown, Oscar G. Wilkins, Colleen Bereda, Cédric Belair, Yong‐Jie Zhang, Mercedes Prudencio, Matthew J. Keuss, Aditya Jignesh Khandeshi, Sarah R. Pickles, Sarah E. Kargbo-Hill, James Hawrot, Daniel M. Ramos, Hebao Yuan, , Michael Emmerson Ward

The paper shows that loss of TDP-43 function leads to the expression of de novo proteins from mis-spliced mRNA transcripts in ALS/FTD.

Science Translational Medicine · Jan 26, 2024Peer-reviewedNeuroscience

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

Dylan V. Neel, Himanish Basu, Georgia Gunner, Matthew Bergstresser, Richard M. Giadone, Haeji Chung, Rui Miao, Vicky Chou, Eliza M. Brody, Xin Jiang, Edward B. Lee, Michelle Evelyn Watts, Christine Marques, Aaron Held, Brian J. Wainger, , Isaac M. Chiu

This study identifies GSDME as a mediator of mitochondrial damage and axon loss in neurodegenerative diseases, showing its role in ALS and FTD models.

Neuron · Mar 13, 2023Peer-reviewedNeuroscience