Author

Ramon S.M. Rooth

Leiden UniversityORCID 0009-0004-8666-5771Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Andy C. H. LiuiD· 1 shared Femke J. BoxmaniD· 1 shared Gianluca TurcoiD· 1 shared Hugo Minnee· 1 shared Isa H. A. RijkiD· 1 shared Jingming LiuiD· 1 shared Mike FiliusiD· 1 shared Monika T. GnatzyiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andy C. H. LiuORCID

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1 paper

Recent·Most cited

Generative Design of High-Affinity Peptides Using BindCraft

Mike Filius, Thanasis Patsos, Hugo Minnee, Gianluca Turco, Jingming Liu, Monika T. Gnatzy, Ramon S.M. Rooth, Andy C. H. Liu, Rosa D. T. Ta, Isa H. A. Rijk, Safiya Ziani, Femke J. Boxman, Sebastian J. Pomplun

This study uses BindCraft to design high-affinity peptides for protein targets, achieving nanomolar affinities for some targets and improving potency through stapling.

bioRxiv · Jul 23, 2025 · PreprintBiochemistry