Sebastian J. Pomplun

PROXINAUT automates hit-to-degrader discovery by integrating library screening with parallel synthesis, resulting in validated degraders with improved binding affinity.

This study uses BindCraft to design high-affinity peptides for protein targets, achieving nanomolar affinities for some targets and improving potency through stapling.

This paper develops DuoMYC, a synthetic miniprotein that inhibits MYC-driven transcription by binding to E-Box DNA with high affinity and stability.