ImmunologyProceedings of the National Academy of SciencesPeer-reviewed
Eosinophil-derived COX-2 protects against experimental colitis through the PGE2-IL-22 axis
Yang Yang, Constance Lynn Atkins, Yuanyuan Fan…·Cynthia Ju
This study identifies eosinophil-derived COX-2 and PGE2 as critical regulators of IL-22 production during colitis, revealing a protective eosinophil-ILC3 crosstalk that safeguards the intestinal barrier.
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