Eosinophil-derived COX-2 protects against experimental colitis through the PGE2-IL-22 axis
Yang Yang, Constance Lynn Atkins, Yuanyuan Fan, Lidan Hou, Jie Zhao, Junda Gao, Yankai Wen, Nicolas F. Moreno, Xiangsheng Huang, Faraz Bishehsari, Agnieszka K. Czopik, Sean P. Colgan, Tuğrul Pürnak, Keith C. Summa, Yingzi Cong, , Cynthia Ju
This study identifies eosinophil-derived COX-2 and PGE2 as critical regulators of IL-22 production during colitis, revealing a protective eosinophil-ILC3 crosstalk that safeguards the intestinal barrier.
Proceedings of the National Academy of Sciences · May 4, 2026Peer-reviewedImmunology