Hydraulic Activation of the AsLOV2 Photoreceptor
Shiny Maity, Jackson Sheppard, Hannah Russell, Chung-Ta Han, Leah Epstein, Bruce A. Johnson, Brad D. Price, Ruixian Han, Lokeswara Rao Potnuru, Jinlei Cui, Mark S. Sherwin, Joan‐Emma Shea, Janet E. Lovett, Kevin H. Gardner, Songi Han
This study shows blue light or high pressure activates AsLOV2 by expelling structured water, causing conformational changes and suggesting hydration water drives protein mechanics.
bioRxiv · Jun 19, 2025 · PreprintBiophysics