Mark S. Sherwin

This paper develops a method to reconstruct time-resolved inter-residue distance distributions in proteins during functional dynamics using rs-TiGGER spectra and applies it to AsLOV2.

This study shows blue light or high pressure activates AsLOV2 by expelling structured water, causing conformational changes and suggesting hydration water drives protein mechanics.

This study identifies ion channels and neurons essential for gravity sensing in C. elegans, showing distinct mechanisms from touch sensation and suggesting evolutionary homology with mammalian systems.