Dual Translational Control in Cardiomyocytes by Heterogeneous mTORC1 and Hypertrophic ERK Activation
Keita Uchida, Emily Anne Scarborough, Elizabeth Pruzinsky, Kathlyene R. Stone, Hali Hartman, Daniel P. Kelly, Jonathan J. Edwards, Izhak Kehat, Benjamin L. Prosser
This study identifies heterogeneous mTORC1 activity and a novel ERK-dependent pathway driving 4EBP1 phosphorylation in cardiomyocytes during hypertrophy, revealing dual translational control mechanisms.
Science Signaling · Apr 21, 2026Peer-reviewedPhysiology