PhysiologyScience SignalingPeer-reviewed
Dual Translational Control in Cardiomyocytes by Heterogeneous mTORC1 and Hypertrophic ERK Activation
Keita Uchida, Emily Anne Scarborough, Elizabeth Pruzinsky…·Benjamin L. Prosser
This study identifies heterogeneous mTORC1 activity and a novel ERK-dependent pathway driving 4EBP1 phosphorylation in cardiomyocytes during hypertrophy, revealing dual translational control mechanisms.
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