A Translational Model of MASLD-Associated HFpEF Defines Mitochondrial Dysfunction and Cardiac Plasticity During Disease Progression and Regression
Souradipta Ganguly, Betul Beyza Gunes, Yusu Gu, Jorge Suárez, Gautam Gupta, Kei Ishizuka, Rabi Murad, Tatiana Kisseleva, Wolfgang H. Dillmann, Kirk L. Peterson, ERIC D. ADLER, David A. Brenner, Debanjan Dhar
This paper develops a mouse model of MASLD-associated HFpEF, showing mitochondrial dysfunction and cardiac plasticity, and demonstrates reversibility with dietary intervention.
Metabolism · Jun 22, 2026Peer-reviewedPhysiology