Yusu Gu

This paper develops a mouse model of MASLD-associated HFpEF, showing mitochondrial dysfunction and cardiac plasticity, and demonstrates reversibility with dietary intervention.

This study shows lipoxins modulate immune responses and cardiac signaling in male MLPko mice with dilated cardiomyopathy, but not in females.

The paper shows that cardiac defects in ATF4 knockout mice result from unintended Rps19bp1 downregulation due to transcriptional readthrough, not loss of ATF4 function.

This study shows RBPMS and RBPMS2 work together to regulate cardiac splicing, with double knockout mice dying in utero due to sarcomere disarray, while single knockouts survive with normal sarcomere structure.