David A. Brenner

This paper develops a mouse model of MASLD-associated HFpEF, showing mitochondrial dysfunction and cardiac plasticity, and demonstrates reversibility with dietary intervention.

This study identifies serine dehydratase (Sds) as a regulator of serine and sphingolipid metabolism, showing that its deletion improves skin repair in diabetic mice.

This study uses single-cell multi-omics to identify cell type-specific regulatory networks and novel therapeutic targets in MASLD.

This study shows LARP6 regulates fibrogenic gene translation in liver fibrosis by interacting with collagen mRNAs and reducing fibrosis in human HSCs.