Duanmiao Si

AlphaCell simulates perturbation-induced cellular dynamics by addressing limitations in current models through three innovations: latent manifold rectification, biological reality reconstruction, and universal state transition.

This paper benchmarks 40 single-cell multi-modal integration algorithms across paired, unpaired, and mosaic datasets to evaluate usability, accuracy, and robustness.

PerturBase is a database that compiles and visualizes single-cell perturbation data from multiple studies, enabling analysis of genetic and chemical perturbations across millions of cells.