A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathway
Erin E. Doherty, Benjamin A. Adler, Peter H. Yoon, Kendall Hsieh, Kenneth J. Loi, Emily G. Armbruster, Arushi Lahiri, Cydni S. Bolling, Xander E. Wilcox, Amogha Akkati, Anthony T. Iavarone, Joe Pogliano, Jennifer A. Doudna
The paper shows that the CRISPR-related enzyme mCpol produces cyclic oligonucleotides to prevent cell death and counteract viral immune evasion.
bioRxiv · Mar 28, 2025 · PreprintBiochemistry