Benjamin A. Adler

A Noncontiguous Code for RNA-Guided DNA Recognition Preceded CRISPR

The paper identifies VIPR systems, which use noncontiguous RNA codes for DNA recognition, suggesting an ancient origin of adaptive immunity through viral interactions.

Divergent viral phosphodiesterases for immune signaling evasion

This study identifies diverse 2H phosphodiesterases in viruses that selectively degrade cyclic dinucleotides to evade host immune signaling.

Recurrent acquisition of nuclease-protease pairs in antiviral immunity

The paper identifies recurrent acquisition of nuclease-protease pairs in bacterial antiviral immunity and shows their proteolytic activation mechanism across different immune systems.

Phage-based microbiome manipulation elucidates interactions within community context

The paper uses phages to manipulate Variovorax species in microbiomes, confirming thiamine interdependencies and laying groundwork for targeted microbiome research.

Viral delivery of an RNA-guided genome editor for transgene-free germline editing in Arabidopsis

This paper engineers a plant virus to deliver a compact CRISPR-Cas system for transgene-free germline editing in Arabidopsis.

A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathway

The paper shows that the CRISPR-related enzyme mCpol produces cyclic oligonucleotides to prevent cell death and counteract viral immune evasion.

An essential and highly selective protein import pathway encoded by nucleus-forming phage

This paper identifies components of a novel protein import pathway in phages, revealing a mechanism for selective protein trafficking into the phage nucleus.

Genetic elements and defense systems drive diversification and evolution in Asgard archaea

This study identifies mobile genetic elements and defense systems in Asgard archaea, revealing their role in shaping genetic diversity and evolution.

Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes

The paper traces the evolutionary origin of eukaryotic RNA-guided endonucleases, showing they evolved from a specific clade of bacterial IS607 TnpB enzymes.

A versatile platform strain for high-fidelity multiplex genome editing

The paper introduces a new bacterial recombineering strain, BioDesignER, with improved efficiency and fidelity for genome editing and engineered function control.