Author

Ruth A. Foley

California NanoSystems InstituteORCID 0000-0002-4271-6045Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Beate IllekiD· 2 shared Brigitte N. GompertsiD· 2 shared Colin J. JuettiD· 2 shared Donald B. KohniD· 2 shared Emily C. DugganiD· 2 shared Lindsay E. LathropiD· 2 shared Paul George AyoubiD· 2 shared Steven John JonasiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

Beate IllekORCID

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2 papers

Recent·Most cited

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site-Specific Integration of CFTR and Mutation-Agnostic Disease Rescue

Ruth A. Foley, Paul George Ayoub, Vrishti Sinha, Colin J. Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin J. Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven John Jonas

This paper develops lipid nanoparticles to deliver CRISPR/Cas9 for site-specific CFTR gene integration in CF airway cells, achieving 3-3.5% gene editing and 80% Cl- current restoration.

Advanced Functional Materials · Jan 4, 2026Peer-reviewedBioengineering

Investigation of Double-Stranded DNA Donors and CRISPR-Cas9 RNP for Universal Correction of Mutations Causing Cystic Fibrosis in Human Airway Cells

Vrishti Sinha, Paul George Ayoub, Colin J. Juett, Lindsay E. Lathrop, Ruth A. Foley, Ruby A. Sims, Joseph D. Long, Emily C. Duggan, Neil Fernandes, Beate Illek, Brigitte N. Gomperts, Steven John Jonas, Donald B. Kohn

This study demonstrates that low levels of CFTR integration can restore chloride ion currents in human airway cells using optimized nonviral CRISPR-Cas9 RNP and double-stranded DNA donors.

bioRxiv · Sep 21, 2025 · PreprintGenetics