Thomas Sakoparnig

The paper identifies sex differences in the choroid plexus across multiple cell types and secretory signaling in mice, with similar patterns observed in humans.

This paper introduces a method to partition single-cell RNA-seq data into statistically distinct gene expression states with no tunable parameters, showing it recovers optimal partitions on synthetic data and identifies subtle substructure in real data.

This study reveals that RNA-bound PGC-1α forms liquid-like nuclear condensates to regulate gene expression and transcriptional networks in response to metabolic stimuli.