Author

Anne‐Claire Doffin

Lyon 1 UniversitéORCID 0009-0005-1446-023XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:spatial domain detection· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Assay:imaging· 2 Assay:spatial transcriptomics· 2 Research Focus:batch correction / integration· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

Christophe CauxiD· 4 shared Jenny Valladeau‐GuilemondiD· 4 shared Justine BerthetiD· 4 shared Bertrand DuboisiD· 3 shared Léo HermetiD· 3 shared Margaux HubertiD· 3 shared Alexia GazeuiD· 2 shared Anaïs EberhardtiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

Christophe CauxORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 7, 2026

Specific dendritic cells spatial organization is associated to ICB Response in Non Small Cell Lung Cancer (NSCLC)

Élisa Gobbini, Pierre Duplouye, Miguel Hurtado…·Jenny Valladeau‐Guilemond

The paper examines the spatial organization of dendritic cell subsets in NSCLC patients treated with anti-PD1 and finds that cDC1-driven patterns correlate with prolonged ICB response.

DOI 10.64898/2026.05.04.720587

humanbulk RNA-seq

𝕏 PostBluesky

BioinformaticsBioinformaticsPeer-reviewedOct 15, 2025

IntegrAlign: A comprehensive tool for multiimmunofluorescence panel integration through image alignment

Léo Hermet, Léo Laoubi, Martial Scavino…·Margaux Hubert

IntegrAlign integrates multiimmunofluorescence panels through image alignment, achieving sub-cellular precision and improving spatial analysis of tumor microenvironments.

DOI 10.1093/bioinformatics/btaf567

imagingexperimental assay

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 7, 2025

Spatial tumour-immune ecosystems shape the efficacy of anti-PD1 immunotherapy in primary cutaneous melanoma

Félix Pham, Marion Dufeu, Valentin Benboubker…·Julie Caramel

This study maps spatial tumour-immune interactions in melanoma and identifies how their organization affects anti-PD1 therapy efficacy.

2 citations

humanspatial transcriptomics

𝕏 PostBluesky

Cancer BiologyCancer Immunology ResearchPeer-reviewedJan 7, 2025

Spatial architecture of CD8+ T cells and DC subsets is critical for the response to immune checkpoint inhibitors in melanoma

Élisa Gobbini, Margaux Hubert, Anne‐Claire Doffin…·Jenny Valladeau‐Guilemond

This study examines the spatial organization of dendritic cell (DC) subsets and their interactions with CD8+ T cells in melanoma patients, finding that proximity between cDC1 and CD8+ T cells correlates with response to immune checkpoint inhibitors.

35 citationstop 1%

humanspatial transcriptomics

𝕏 PostBluesky