PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation
Rui Fang, Tuulia Vallius, Arianna Zhang, Devon Van Cura, Francisco Alicandri, Grant M. Fischer, Elizabeth C. Draper, Shuyun Xu, Roxanne J. Pelletier, Justina Wang, Anna Mandinova, Igor Katsyv, Peter Karl Sorger, Gëorge F. Murphy, Christine Guo Lian
This study shows PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation, with reduced 5hmC levels correlating with PRAME upregulation.
Laboratory Investigation · Jul 26, 2024Peer-reviewedCancer Biology