This study shows that the concave topography of rete ridges influences epidermal stem cell differentiation and function, with changes in topography contributing to skin aging.

bioRxiv · Apr 10, 2026 · PreprintCell Biology

Episodic Transport of Protein Aggregates Achieves a Positive Size Selectivity in Aggresome Formation

Rui Fang, Luolan Bai, Bert M. Verheijen, Boyan Li, Kevin D. Dong, João A. Paulo, Mengying Zhou, Yi-Chi Chu, Yuyu Song, Michael Y. Sherman, Steven P. Gygi, Christine M. Field, Timothy John Mitchison, Ying Lu

The paper investigates aggresome formation by reconstituting aggregate transport in Xenopus egg extract, finding that episodic dynein-mediated transport enables positive size selectivity.

Nature Communications · Aug 22, 2025Peer-reviewedCell Biology

PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation

Rui Fang, Tuulia Vallius, Arianna Zhang, Devon Van Cura, Francisco Alicandri, Grant M. Fischer, Elizabeth C. Draper, Shuyun Xu, Roxanne J. Pelletier, Justina Wang, Anna Mandinova, Igor Katsyv, Peter Karl Sorger, Gëorge F. Murphy, Christine Guo Lian

This study shows PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation, with reduced 5hmC levels correlating with PRAME upregulation.

Laboratory Investigation · Jul 26, 2024Peer-reviewedCancer Biology