Author
Broad InstituteORCID 0000-0001-9273-0972Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Emery Di Cicco, Jovan Isma, Stefano Sol…·Gian Paolo Dotto
This study identifies the TERRA-NONO axis as a driver of fibroblast reprogramming into cancer-associated fibroblasts, showing its therapeutic potential in multiple cancers.
Li Li, Zhengkuan Tang, Xavier Portillo…·George McDonald Church
This paper presents a single-cell atlas of skin aging and identifies ATF3 as a regulator of aging, leading to an mRNA-based treatment that reduces cell senescence and enhances skin rejuvenation.
Rui Fang, Ryoko Hamaguchi, S. Xu…·Christine Guo Lian
This study shows that the concave topography of rete ridges influences epidermal stem cell differentiation and function, with changes in topography contributing to skin aging.
Rui Fang, Tuulia Vallius, Arianna Zhang…·Christine Guo Lian
This study shows PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation, with reduced 5hmC levels correlating with PRAME upregulation.