Author

Xingjian Li

First Affiliated Hospital of Guangzhou Medical UniversityORCID 0009-0005-3040-8968Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Xianting LiiD· 2 shared Yuanxi ZhangiD· 2 shared Zhenyu YueiD· 2 shared Bik Tzu HuangiD· 1 shared Duc Tung VuiD· 1 shared George R. Heaton· 1 shared Haiyan TaniD· 1 shared Hanwen ZhuiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Xianting LiORCID

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2 papers

Recent·Most cited

Molecular BiologyJournal of Clinical InvestigationPeer-reviewedSep 30, 2025

Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant

George R. Heaton, Xingjian Li, Xianting Li…·Zhenyu Yue

This study investigates how the LRRK2-N2081D variant increases Crohn's disease risk by showing it causes more severe colitis and distinct RAB substrate phosphorylation compared to LRRK2-G2019S.

5 citations

mouseexperimental assay

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NeuroscienceNature CommunicationsPeer-reviewedSep 29, 2024

RAB12-LRRK2 Complex Suppresses Primary Ciliogenesis and Regulates Centrosome Homeostasis in Astrocytes

Xingjian Li, Hanwen Zhu, Bik Tzu Huang…·Zhenyu Yue

This study identifies RAB12 as a LRRK2 substrate in mouse brains, shows its role in suppressing ciliogenesis and regulating centrosome homeostasis in astrocytes, and demonstrates that disrupting RAB12 mitigates PD-linked LRRK2 mutation effects.

23 citationstop 3%

mousestatistical model

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