Bik Tzu Huang

This study identifies RAB12 as a LRRK2 substrate in mouse brains, shows its role in suppressing ciliogenesis and regulating centrosome homeostasis in astrocytes, and demonstrates that disrupting RAB12 mitigates PD-linked LRRK2 mutation effects.

The paper identifies small molecules that inhibit proteotoxicity and inflammation in Alzheimer's Disease models, revealing mechanisms linking glycolysis to neuroinflammation and suggesting new therapeutic targets.