Author

George R. Heaton

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Adamantios MamaisiD· 1 shared Alexandra G. BeilinaiD· 1 shared Duc Tung VuiD· 1 shared Inga PeteriD· 1 shared Jonathon Nixon‐AbelliD· 1 shared Kirsten HarveyiD· 1 shared Laura PellegriniiD· 1 shared Leonid TarassishiniD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Adamantios MamaisORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant

George R. Heaton, Xingjian Li, Xianting Li, Xiaoting Zhou, Yuanxi Zhang, Duc Tung Vu, Marc Oeller, Özge Karayel, Quyen Q. Hoang, Meltem Ece Kars, Nitika Kamath, Minghui Wang, Leonid Tarassishin, Matthias Mann, Inga Peter, Zhenyu Yue

This study investigates how the LRRK2-N2081D variant increases Crohn's disease risk by showing it causes more severe colitis and distinct RAB substrate phosphorylation compared to LRRK2-G2019S.

Journal of Clinical Investigation · Sep 30, 2025Peer-reviewedMolecular Biology

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

George R. Heaton, Natalie Landeck, Adamantios Mamais, Mike A. Nalls, Jonathon Nixon‐Abell, Ravindran Kumaran, Alexandra G. Beilina, Laura Pellegrini, Yan Li, Kirsten Harvey, Mark Cookson

The paper identifies LRRK2 as a regulator of clathrin-mediated endocytosis and links clathrin-trafficking pathways to Parkinson's disease risk.

Neurobiology of Disease · May 17, 2020Peer-reviewedMolecular Biology