Hanwen Zhu

Elucidating the molecular interplay between LRRK2 and Rab GTPases

This study identifies six distinct Rab-binding sites on LRRK2 and a GABARAP-binding site, revealing molecular mechanisms of Rab recognition and potential therapeutic targets for Parkinson's disease.

Exploring multi-level microbial interactions from individual 3D genomes to community networks

This study introduces FindMeta3D to analyze microbial 3D genomes and cross-domain interactions, revealing conserved chromatin patterns and infection-related hotspots with therapeutic implications.

CellPatch: a Highly Efficient Foundation Model for Single-Cell Transcriptomics with Heuristic Patching

CellPatch is a lightweight foundation model for single-cell transcriptomics that achieves state-of-the-art performance with low computational costs.

RAB12-LRRK2 Complex Suppresses Primary Ciliogenesis and Regulates Centrosome Homeostasis in Astrocytes

This study identifies RAB12 as a LRRK2 substrate in mouse brains, shows its role in suppressing ciliogenesis and regulating centrosome homeostasis in astrocytes, and demonstrates that disrupting RAB12 mitigates PD-linked LRRK2 mutation effects.

Assessing base-resolution DNA mechanics on the genome scale

The paper introduces BendNet, a neural network that predicts DNA bending at base-resolution from sequences, revealing stiffness patterns and TF binding preferences in the human genome.