Cancer BiologybioRxivPreprint
Gastric epithelium from BRCA1 and BRCA2 carriers harbors increased double-stranded DNA damage and augmented growth.
Kole H. Buckley, Michaela E. Dungan, Kevin Dinh…·Bryson W. Katona
This study finds BRCA1 and BRCA2 carriers have increased DNA damage and growth in gastric epithelium and organoids, suggesting haploinsufficiency contributes to early gastric cancer development.
DOI 10.1101/2025.10.01.679809