Gastric epithelium from BRCA1 and BRCA2 carriers harbors increased double-stranded DNA damage and augmented growth.
Kole H. Buckley, Michaela E. Dungan, Kevin Dinh, Gregory M. Kelly, Ryan M. Hausler, Kate E Bennett, Daniel G. Clay, Julia E Youngman, Ariana D. Majer, Keely A. Beyries, Blake A. Niccum, Sydney M. Shaffer, Tatiana A. Karakasheva, Kathryn E. Hamilton, Michael L. Kochman, , Bryson W. Katona
This study finds BRCA1 and BRCA2 carriers have increased DNA damage and growth in gastric epithelium and organoids, suggesting haploinsufficiency contributes to early gastric cancer development.
bioRxiv · Oct 1, 2025 · PreprintCancer Biology