Author

Federica Bruno

The Francis Crick InstituteORCID 0009-0005-4241-3107Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Christiana GeorgiouiD· 3 shared Cristina Lo CelsoiD· 3 shared Flora BirchiD· 3 shared Constandina PosporiiD· 2 shared Sara González Antón· 2 shared Andrew M. BlagboroughiD· 1 shared Berthold GöttgensiD· 1 shared Beth Payne· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCell Biology

Christiana GeorgiouORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintApr 9, 2025

A subset of Haematopoietic Stem Cells resists Plasmodium infection-induced stress by uncoupling interferon sensing and metabolic activation

Christiana Georgiou, Qi Liu, Sara González Antón…·Cristina Lo Celso

The paper identifies two HSC subsets with distinct responses to Plasmodium infection, showing that BiotinHi HSCs remain functional by maintaining a stemness-associated metabolic profile despite sensing inflammation.

DOI 10.1101/2025.04.09.647965

mousescRNA-seq

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Developmental BiologybioRxivPreprintSep 25, 2024

Differential responses and recovery dynamics of HSPC populations following Plasmodium chabaudi infection.

Federica Bruno, Christiana Georgiou, Deirdre Cunningham…·Cristina Lo Celso

This study examines how hematopoietic stem and progenitor cells (HSPCs) respond and recover following Plasmodium chabaudi infection, revealing distinct recovery patterns and changes in proliferation rates.

1 citation

mousebulk RNA-seq

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Cancer BiologybioRxivPreprintSep 15, 2024

SIRPalpha+ PD-L1+ bone marrow macrophages aid AML growth by modulating T cell function

Flora Birch, Sara González-Antón, Myriam Luydmila Rachelle Haltalli…·Cristina Lo Celso

The paper identifies a subpopulation of bone marrow macrophages that support AML growth by inhibiting T cells and are enriched in patients with early relapse.

1 citation

humanflow cytometry

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