Cristina Lo Celso

The paper uses intravital microscopy and statistical image analysis to study early HSC engraftment, revealing dynamic cellular behaviors linked to differentiation over time.

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

The paper shows clonal memory in human HSPCs persists across divisions and is disrupted in AML, with potential for therapeutic modulation.

This study optimizes the waiting time between dual-pulse nucleoside labeling pulses to improve signal-to-noise ratio in cell cycle analysis, particularly for experiments with small cell numbers.

This paper introduces a dual-view oblique plane microscope for high-resolution imaging of thick cleared tissue samples across multiple species.

This paper introduces a double reporter strategy to identify a non-migratory subset of hematopoietic stem cells in the bone marrow niche and shows their dynamic interactions during stress and aging.

The paper identifies two HSC subsets with distinct responses to Plasmodium infection, showing that BiotinHi HSCs remain functional by maintaining a stemness-associated metabolic profile despite sensing inflammation.

This study examines how hematopoietic stem and progenitor cells (HSPCs) respond and recover following Plasmodium chabaudi infection, revealing distinct recovery patterns and changes in proliferation rates.

The paper identifies a subpopulation of bone marrow macrophages that support AML growth by inhibiting T cells and are enriched in patients with early relapse.

This study investigates how malaria infection alters the bone marrow microenvironment, leading to impaired haematopoietic stem cell function through changes in endothelium and osteoblasts.

The paper uses single-cell tracking to show that HSCs from infected mice exhibit heterogeneous movement patterns compared to controls, with increased persistence possibly aiding survival in altered niche environments.