Flora Birch

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

The paper identifies two HSC subsets with distinct responses to Plasmodium infection, showing that BiotinHi HSCs remain functional by maintaining a stemness-associated metabolic profile despite sensing inflammation.

This paper develops T-SenSER, a synthetic biosensor for T cells that enhances anti-tumor responses by sensing TME factors like VEGF and CSF1, showing improved efficacy in lung cancer and multiple myeloma models.

This study examines how hematopoietic stem and progenitor cells (HSPCs) respond and recover following Plasmodium chabaudi infection, revealing distinct recovery patterns and changes in proliferation rates.

The paper identifies a subpopulation of bone marrow macrophages that support AML growth by inhibiting T cells and are enriched in patients with early relapse.