Constandina Pospori

The paper uses intravital microscopy and statistical image analysis to study early HSC engraftment, revealing dynamic cellular behaviors linked to differentiation over time.

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

The paper shows clonal memory in human HSPCs persists across divisions and is disrupted in AML, with potential for therapeutic modulation.

This study optimizes the waiting time between dual-pulse nucleoside labeling pulses to improve signal-to-noise ratio in cell cycle analysis, particularly for experiments with small cell numbers.

This study identifies neutrophil-driven systemic conditioning that links inflammation, tissue regeneration, and metastasis, with UPP1 as a key factor in neutrophil priming.

The paper identifies two HSC subsets with distinct responses to Plasmodium infection, showing that BiotinHi HSCs remain functional by maintaining a stemness-associated metabolic profile despite sensing inflammation.

The paper identifies a subpopulation of bone marrow macrophages that support AML growth by inhibiting T cells and are enriched in patients with early relapse.