Anna‐Friederike Marx

This paper re-engineers a cytolytic viral vector to be non-cytolytic, enhancing CD8 T cell immunity through reinforced type I IFN signaling.

This study shows that chronic viral infection disrupts B cell affinity hierarchies by preferentially causing attrition of high-affinity B cells due to excessive antigen stimulation.

This study introduces depletion-AAVs to permanently eliminate lymphocyte subsets in mice, showing B cells are critical for CD4 and CD8 T cell responses to chronic viral infection.