Author

Tiago Abreu-Mota

University of BaselORCID 0000-0002-0891-4734Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Anna‐Friederike MarxiD· 3 shared Daniel D. PinscheweriD· 3 shared Doron MerkleriD· 3 shared Ingrid WagneriD· 3 shared Anna Lena KastneriD· 2 shared Jonas FixemeriD· 2 shared Karsten Stauffer· 2 shared Matías CiancagliniiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Anna‐Friederike MarxORCID

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3 papers

Recent·Most cited

Non-cytolytic re-engineering of a viral vaccine vector enables durable effector-memory T cell immunity by reinforcing type I IFN induction

Matías Ciancaglini, Robin Avanthay, Anna‐Friederike Marx, Tiago Abreu-Mota, Davide Finozzi, Jonas Fixemer, Florian M. Geier, Dominik Bürri, Ingrid Wagner, Ilena Vincenti, Mario Kreuzfeldt, Doron Merkler, Gert Zimmer, Daniel D. Pinschewer

This paper re-engineers a cytolytic viral vector to be non-cytolytic, enhancing CD8 T cell immunity through reinforced type I IFN signaling.

Molecular Therapy — Nucleic Acids · Feb 3, 2026Peer-reviewedImmunology

Chronic Infection Perturbs the Affinity Hierarchy of Antiviral B Cells

Mirela Dimitrova, Tiago Abreu-Mota, Jonas Fixemer, Weldy V. Bonilla, Anna‐Friederike Marx, Min Lu, Karen Tintignac, Anna Lena Kastner, Yusuf I. Ertuna, Marianna Florova, Matías Ciancaglini, Kerstin Narr, Karsten Stauffer, Julien Roux, Philippe Demougin, , Daniel D. Pinschewer

This study shows that chronic viral infection disrupts B cell affinity hierarchies by preferentially causing attrition of high-affinity B cells due to excessive antigen stimulation.

bioRxiv · Aug 21, 2025 · PreprintImmunology

Permanent lymphocyte subset elimination upon a single dose of AAV-delivered depletion antibody dissects immune control of chronic viral infection

Anna Lena Kastner, Anna‐Friederike Marx, Mirela Dimitrova, Tiago Abreu-Mota, Yusuf I. Ertuna, Weldy V. Bonilla, Karsten Stauffer, Marco Künzli, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Daniel D. Pinschewer

This study introduces depletion-AAVs to permanently eliminate lymphocyte subsets in mice, showing B cells are critical for CD4 and CD8 T cell responses to chronic viral infection.

Immunity · Dec 24, 2024Peer-reviewedImmunology