Matthew I. McFadden

This study shows that gasdermin E is not essential for H1N1 influenza virus pathogenesis in mice, as Gsdme-/- mice exhibit similar infection outcomes to wild-type mice.

This study shows that activating AMPK in mice infected with a modified H1N1 virus reduces cardiac damage by restoring mitochondrial function and improving survival.

This study shows that IFITM3 deficiency accelerates SARS-CoV-2 adaptation in mice, revealing how variant traits influence tropism and pathogenesis across hosts.

The paper identifies ERK5 as a potentiator of STAT1 activation and ISG expression, enhancing type III IFN-mediated antiviral responses in epithelial cells.