Fibroblast Activation Protein Defines an Aggressive, Immunosuppressive EMT-associated Tumor Subtype in Highly Inflamed Localized Clear Cell Renal Cell Carcinoma
Teijo S. Pellinen, Lassi Luomala, Kalle Mattila, Annabrita Hemmes, Katja E. Välimäki, Oscar E. Brück, Lassi Paavolainen, Elisa Kankkunen, Harry Nísen, Petrus Järvinen, Leticia Castillon, Sakari Vanharanta, Paula Vainio, Olli Kallioniemi, Panu Jaakkola, Tuomas K. Mirtti
The paper identifies FAP-expressing EMT-associated cancer cells in highly inflamed localized ccRCC as an aggressive, immunosuppressive subtype linked to poor prognosis and metastasis.
bioRxiv · Oct 27, 2024 · PreprintCancer Biology