Author

Leticia Castillon

University of HelsinkiORCID 0009-0007-2110-3825Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Sakari VanharantaiD· 2 shared Anna C. ObenaufiD· 1 shared Anna Dyas· 1 shared Annabrita HemmesiD· 1 shared Cissy YongiD· 1 shared Daniel Muñoz‐EspíniD· 1 shared Elisa KankkuneniD· 1 shared Grant Duncan StewartiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Sakari VanharantaORCID

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2 papers

Recent·Most cited

Cancer BiologyEMBO Molecular MedicinePeer-reviewedDec 19, 2025

Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities

Jianfeng Ge, Shoko Hirosue, Leticia Castillon…·Sakari Vanharanta

This study identifies HIF1A as a key inhibitor of VHL null cell fitness and shows that combined VHL/HIF1A inactivation can confer resistance to PROTAC-based therapies.

3 citations

humangenetic perturbation / CRISPR

𝕏 PostBluesky

Cancer BiologybioRxivPreprintOct 27, 2024

Fibroblast Activation Protein Defines an Aggressive, Immunosuppressive EMT-associated Tumor Subtype in Highly Inflamed Localized Clear Cell Renal Cell Carcinoma

Teijo S. Pellinen, Lassi Luomala, Kalle Mattila…·Tuomas K. Mirtti

The paper identifies FAP-expressing EMT-associated cancer cells in highly inflamed localized ccRCC as an aggressive, immunosuppressive subtype linked to poor prognosis and metastasis.

5 citations

humanspatial transcriptomics

𝕏 PostBluesky