Jan‐Niklas Tants

This paper investigates how Roquin's two ROQ domains interact with different regions of the Ox40 mRNA 3UTR, revealing opposing effects on RNA structure stability and mRNA decay.

This study investigates how the RNA alternative decay element (ADE) evolved to become a high-affinity target for Roquin, revealing structural determinants and the role of a second RNA-binding interface in ADE recognition.

This study determines the structure of the Roquin ZnF domain and shows it binds AU-rich elements, revealing how Roquin integrates RNA shape and sequence specificity through its ROQ-ZnF tandem.