Author

Costanza Lo Cascio

Broad InstituteORCID 0009-0005-5161-6117Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:deep learning· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Carlos Alberto Oliveira de BiagiiD· 3 shared Mariella G. FilbiniD· 3 shared Jacob S RozowskyiD· 2 shared Johannes GojoiD· 2 shared Shashank KatiyariD· 2 shared Abigail E. RogersiD· 1 shared Adam C Resnick· 1 shared Alexandre Ravel· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

Carlos Alberto Oliveira de BiagiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 16, 2026

Single-cell multi-omic analyses resolve the cellular diversity of ALK/ROS1/MET/NTRK-fused gliomas in infants and older children

Andrea Joseph De Micheli, Carlos Alberto Oliveira de Biagi, Costanza Lo Cascio…·Ana Guerreiro Stücklin

The paper uses single-cell and spatial multi-omic analyses to characterize cellular diversity in RTK-fused gliomas across pediatric age groups, identifying distinct cancer cell states and myeloid subgroups.

DOI 10.64898/2026.07.16.738862

humanscRNA-seq

𝕏 PostBluesky

Cancer BiologyNaturePeer-reviewedMar 11, 2026

Single-cell multidimensional profiling of tumor cell heterogeneity in supratentorial ependymomas

Daeun Jeong, Sara G. Danielli, Kendra K. Maaß…·Mariella G. Filbin

This study integrates single-cell and spatial transcriptomics with live-cell imaging to characterize tumor heterogeneity in supratentorial ependymomas, revealing distinct progenitor-like states and spatial organization patterns.

5 citationstop 1%

humanscRNA-seq

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NeurosciencebioRxivPreprintDec 12, 2025

Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology

Richard Drexler, Belgin Yalçın, Rebecca A. Mancusi…·Michelle Monje

This study shows serotonergic neurons promote high-grade glioma growth via 5HT2A receptor activation, with psychedelic drugs enhancing this effect.

5 citations

mousebulk RNA-seq

𝕏 PostBluesky