Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology
Richard Drexler, Belgin Yalçın, Rebecca A. Mancusi, Abigail E. Rogers, Kiarash Shamardani, Pamelyn J. Woo, Alexandre Ravel, Samuel Wu, Yahaya Abubakar Yabo, Lisa Steger, Carlos Alberto Oliveira de Biagi, Costanza Lo Cascio, Robert C. Malenka, Boris Dov Heifets, Mariella G. Filbin, , Michelle Monje
This study shows serotonergic neurons promote high-grade glioma growth via 5HT2A receptor activation, with psychedelic drugs enhancing this effect.
bioRxiv · Dec 12, 2025 · PreprintNeuroscience